Author: Matta C, Lewis R, Fellows C, Diszhazi G, Almassy J, Miosge N, Dixon J, Uribe M C, May S, Poliska S, Barrett-Jolley R, Fodor J, Szentesi P, Hajdú T, Keller-Pinter A, Henslee E, Labeed F H, Hughes M P, Mobasheri A.
Journal of Cellular Physiology, 2021
Matta and colleagues investigated whether chondrogenic progenitor cells (CPCs) could be an alternative to mesenchymal stem cells (MSCs) as a cell source for regenerative therapies targeting articular cartilage. In this study, the profiles of ion channels and transporters that may be relevant to chondrogenesis were studied for both cell types. Random migration of CPCs was monitored using the CytoSMART Lux2, identifying the investigated cells as migratory CPCs. Addition of paxilline – an inhibitor of large-conductance calcium-activated potassium channels – increased the cell motility and compromised the CPC phenotype. All in all, many similarities between CPCs and MSCs were found, even though the CPCs were shown to be a distinct cell population.
