Authors: Xia H, Zhang Z, You F.
National Library of Medicine, 2021
In this study, Xia and colleagues utilized murine macrophages and a C576BL/6 mice intranasal infection model to establish whether ferroptosis, a form of lytic cell death, was involved in the pathogenicity of murine hepatitis virus strain 59 (MHV-A59). MHV-A59 is an extensively studied coronavirus infection model. The CytoSMART Lux2 with its integrated cell confluence algorithm was used to monitor primary peritoneal macrophages (PMs) and determine the extent of syncytia formation. All in all, this study indicates that ferroptosis inhibition protects hosts from MHV-A59 infection, and may serve as a potential therapeutic target.
