MicroRNA-375 repression of Kruppel-like factor 5 improves angiogenesis in diabetic critical limb ischemia

Author: McCoy, M.G., Jamaiyar, A., Sausen, G., Cheng, H.S., Pérez-Cremades, D., Zhuang, R., Chen, J., Goodney, P.P., Creager, M.A., Sabatine, M.S. and Bonaca, M.P.

Angiogenesis, 2022


The authors of this study investigated the intramuscular delivery of miR-375 to improve angiogenesis in a diabetic mouse limb ischemia model. The CytoSMART Omni was used in the quantification of endothelial wound closure, spheroid sprouting and network formation in HUVECs. The results indicate that miR-375 overexpression leads to an augmentation of these processes, supporting that miR-375 facilitates vessel growth and angiogenesis. All in all, delivery of miR-375 may be a potential therapeutic target for treating human diabetic patients at risk of critical limb ischemia.