Authors: Drews HJ, Klein R, Lourhmati A, Buadze M, Schaeffeler E, Lang T, Seferyan T, Hanson LR, Frey II WH, de Vries TCGM, Thijssen-van Loosdregt IAEW, Gleiter CH, Schwab M, Danielyan L.
Pharmaceuticals. 2021; 14(2):166
In this publication, the authors utilized CytoSMART Lux3FL fluorescence imager to track the migration of cells from astroglial primary cultures derived from wild-type mice and from triple-transgenic Alzheimer’s disease mice. These cell cultures were treated with the angiotensin receptor blocker, losartan, to study its effect on astrocyte motility. Live-cell imaging revealed that the motility and velocity of losartan-treated cells were greater when compared to the non-treated controls. Overall, these results suggest that losartan positively affects the migrational capacity of astrocytes affected by amyloid beta.
