Author: Fänder, J., Kielstein, H., Büttner, M., Koelblinger, P., Dummer, R., Bauer, M., Handke, D., Wickenhauser, C., Seliger, B. and Jasinski-Bergner, S.
Oncotarget, 2019
The authors of this study investigated the effect of CD44 regulatory microRNA on melanoma cell proliferation, migration and apoptosis to find potential novel microRNA-based anti-cancer drugs. The CytoSMART Lux2 was used to investigate the effect of the microRNA miR-143-3p on cell migration. miR-143-3p overexpression in the BLM melanoma cell line led to a reduction in cell proliferation and migration and an enhanced apoptosis. Altogether, the tumour suppressive miR-143-3p was identified as a potent CD44 inhibitory microRNA for treatment of malignant melanoma.
