Bioluminescent RAPPID Sensors for the Single-Step Detection of Soluble Axl and Multiplex Analysis of Cell Surface Cancer Biomarkers

Author: van Aalen E A, Wouters S F A, Verzijl D, Merkx M.

Analytical Chemistry, 2022


The authors of this study aimed to extend a previously developed screening platform to detect the soluble fraction of Axl (sAxl) and EGFR on cellular membranes. The CytoSMART Exact (formerly known as the Corning Cell Counter) was used to count cells used to quantify the amount of Axl and EGFR on the cell membranes. All in all, the RAPPID system was expanded to detect Axl in early stages of different types of cancer.