RESOURCES
Immunization by vaccination is widely recognized as one of the world’s greatest public health achievements. The first part of this two-part series on the use of live-cell imaging in vaccine research provides a succinct review of history and immunology as they relate to the development of vaccines.
Learn more
RESOURCES
Many important dynamic cellular events can be studied using long-term live-cell imaging. In contrast to endpoint assays, long-term live-cell imaging provides a more complete picture of dynamic biological processes through greater spatial and temporal resolution.
Learn more
RESOURCES
Chimeric antigen receptor (CAR) T cell therapy is a rapidly emerging treatment modality that uses genetically engineered T cells to specifically target and kill cancer cells. The invention of CAR T cell-based immunotherapy has revolutionized the field of personalized cancer treatment. This article focuses on the history and clinical applications of CAR T cell therapy, as well as the application of live-cell imaging in CAR T cell research.
Learn more
RESOURCES
The term “cytotoxicity” refers to toxicity to cells, thereby investigating whether the exogenous agents do not interfere with healthy cell function and do not cause apoptotic or necrotic cell death. This article provides a summary of the basic principles, approaches, and methods of in vitro cytotoxicity assays.
Learn more
RESOURCES
Live-cell imaging is a technique, whereby the cells are imaged when they are alive, typically in the growth medium. In recent years, live-cell imaging has become a requisite analytical tool for addressing important questions in several areas of biological and biomedical sciences including cancer research, neuroscience, cell biology, developmental biology, and pharmacology.
Learn more
RESOURCES
Automated cell counters have become very popular research tools, however, many labs are still hesitating to invest in an automated cell counter. This article summarizes the key points that need to be considered when deciding between an automated or manual setup.
Learn more
RESOURCES
Cell therapy has broad applications that range from treating cancer, diabetes, cardiovascular and neurogenerative conditions to tissue regeneration and replacement. CytoSMART offers an excellent range of live-cell imaging systems that can be used to research and manufacture cell therapies. The applications and examples of these live-cell imaging systems will be discussed below.
Learn more
RESOURCES
This article highlights considerations for more sustainable live-cell imaging. Live-cell imaging enables researchers to determine not only whether, but also when and how certain cellular events occur in culture. Therefore, this technique is increasingly applied in cell research. The environmental footprint of live-cell imaging can be large, although more sustainable alternatives are also available within this experimental procedure. When looking for a live-cell imaging system, the following 5 factors can already increase sustainability with minimal effort: light source, connected computer, data storage, remote monitoring and analysis, and system complexity.
Learn more
RESOURCES
Laboratory automation is becoming a new reality in scientific research, due to the rapid technological advancement and the numerous benefits offered by this strategy. Here, we explain relevant commonly used terms in the field of laboratory automation, provide factors to be considered before automating a laboratory, summarize requirements for a successfully automated laboratory, and identify typical laboratories and sectors that fulfil the requirements and, therefore, could be easily and successfully automated.
Learn more
RESOURCES
A recent study by Drews et al. (2021) focuses on examining broad neuroprotective qualities of losartan. The CytoSMART Lux3 FL fluorescence live-cell imager was used to monitor the motility of Aβ-affected astrocytes. To learn more about the use of the CytoSMART devices in life sciences, we asked Dr. Lusine Danielyan a few questions about her experience with using the Lux3 FL for live-cell imaging.
Learn more
