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CAR T cell therapy: combating cancer with engineered immune cells

Chimeric antigen receptor (CAR) T cell therapy is a rapidly emerging treatment modality that uses genetically engineered T cells to specifically target and kill cancer cells. The invention of CAR T cell-based immunotherapy has revolutionized the field of personalized cancer treatment. This article focuses on the history and clinical applications of CAR T cell therapy, as well as the application of live-cell imaging in CAR T cell research.

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Live-cell imaging: illuminating cells in real time

Live-cell imaging is a technique, whereby the cells are imaged when they are alive, typically in the growth medium. In recent years, live-cell imaging has become a requisite analytical tool for addressing important questions in several areas of biological and biomedical sciences including cancer research, neuroscience, cell biology, developmental biology, and pharmacology.

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Manual vs automated cell counting, is there a great divide?

Automated cell counters have become very popular research tools, however, many labs are still hesitating to invest in an automated cell counter. This article summarizes the key points that need to be considered when deciding between an automated or manual setup.

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Live-cell imaging in the field of cell therapy

Cell therapy has broad applications that range from treating cancer, diabetes, cardiovascular and neurogenerative conditions to tissue regeneration and replacement. CytoSMART offers an excellent range of live-cell imaging systems that can be used to research and manufacture cell therapies. The applications and examples of these live-cell imaging systems will be discussed below.

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5 factors to consider when choosing a sustainable live-cell imaging system

This article highlights considerations for more sustainable live-cell imaging. Live-cell imaging enables researchers to determine not only whether, but also when and how certain cellular events occur in culture. Therefore, this technique is increasingly applied in cell research. The environmental footprint of live-cell imaging can be large, although more sustainable alternatives are also available within this experimental procedure. When looking for a live-cell imaging system, the following 5 factors can already increase sustainability with minimal effort: light source, connected computer, data storage, remote monitoring and analysis, and system complexity.

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To automate, or not to automate, that’s the question

Laboratory automation is becoming a new reality in scientific research, due to the rapid technological advancement and the numerous benefits offered by this strategy. Here, we explain relevant commonly used terms in the field of laboratory automation, provide factors to be considered before automating a laboratory, summarize requirements for a successfully automated laboratory, and identify typical laboratories and sectors that fulfil the requirements and, therefore, could be easily and successfully automated.

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Visualizing astroglial motility in a mouse model of Alzheimer's disease using live-cell imaging [Interview with Dr. Lusine Danielyan]

A recent study by Drews et al. (2021) focuses on examining broad neuroprotective qualities of losartan. The CytoSMART Lux3 FL fluorescence live-cell imager was used to monitor the motility of Aβ-affected astrocytes. To learn more about the use of the CytoSMART devices in life sciences, we asked Dr. Lusine Danielyan a few questions about her experience with using the Lux3 FL for live-cell imaging.

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