Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages

Authors: Matsumoto S, Traber MG, Leonard SW, Choi J, Fang x, Maishan M, Wick KD, Jones KD, Calfee CS, Gotts JE, Matthay MA.

National Library of Medicine, 2022


Vitamin E acetate (VEA) is thought to play a causal role in the development of vaping-associated lung injury. The authors of this study aimed to identify the exact mechanisms promoting VEA-related lung injury. The Exact (former Corning cell counter) was used to count bronchoalveolar lavage (BAL) cells. The results suggested that extended exposure to VEA aerosol produced systemic inflammation and evidence of systemic oxidative stress in mice, providing evidence of these processes as possible pathways for the harmful effects of VEA in smokers.