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Organoids: definition, culturing methods, and clinical applications

Organoids are three-dimensional cell structures, containing a multitude of organ-specific cells, which are formed by self-organization and differentiation of stem cells. Producing organoids in the lab is dependent on the goals of the researcher, and several considerations will be discussed in this article, including organoid culturing, characterization, and their clinical potential.

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Clonogenic (colony formation) assay for stem cells

Although colony formation assay is more widely known as a cancer biology assay, it does have applications in the field of stem cell biology, where the self-renewal potential of stem cells and their progenitors is assessed. Colony formation assays that are used in this context are not endpoint-based and rely on live-cell imaging. These assays enable the selection of desired colonies for further culturing and experimentation. Assessing colony formation is most commonly used for hematopoietic stem cells (HSCs), in the form of a colony formation unit (CFU) assay.

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CytoSMART Cloud security

CytoSMART devices are connected to the Microsoft Azure cloud environment. In this article, we discuss cloud safety, privacy, and international compliance.

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Spheroids: properties, image analysis, and culture methods

Spheroids have become an exciting cell culture model, as they better mimic in vivo tissue properties and exhibit a superior capacity for differentiation compared to 2D culture systems. These properties make them well suited for use in drug development and tissue engineering studies, as well as for the study of fundamental biological principles.

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Neural stem cells

The establishment of protocols for the extraction or differentiation of neural stem cells (NSCs) and their expansion in vitro was a great advancement in neurobiology. NSCs grown in culture provide a powerful tool and an accessible model to investigate human neurodevelopment and cell biology. This article discusses neural stem cell sources, isolation, culture methods, and differentiation potential.

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Human umbilical cord mesenchymal stem cells

In this article, we will discuss the clinical use, isolation, and culturing of hUC-MSCs. It will become clear that following a strict culturing protocol, sticking to specific seeding densities, and observing confluence is essential to maintaining stemness of the MSCs.

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