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Modes of Cell Migration

Cell migration is an essential process involved in important physiological processes such as embryogenesis, angiogenesis, wound healing and the immune response. Cells migrate in different modes depending on the type and function of the cells. Leukocytes, for example, migrate the majority of their life span as single cells within virtually any tissue in the body. Many other cell types only move at specific situations to place, shape or repair tissue. Most of these cells move in groups that are loosely or closely associated. This type of migration is called collective cell migration. In this article, different modes of both single cell migration and collective cell migration are discussed.

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Wound healing assay - what, why and how

The wound-healing assay is a convenient and economical method to investigate collective cell migration under different experimental conditions. As collective cell migration is linked to many physiological and pathological processes related to embryogenesis, wound repair and cancer metastasis, the wound healing assay is broadly applicable. We discuss how to set up an experiment and several options to analyze imaging data.

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